Perthro 
translates to lot cup, like shaking the dice in a cup, karma, choices, destiny, transformation
Raido 
is associated with a journey & making it through the trip safely, justice, vitality
Isa 
is stillness, challenges, stalemate, forced rest, introspection
Ansuz 
is blessings, knowledge from the divine, inspiration.
Runes Information has a list of all the Runes & their meanings/keywords/upright/reversed.
I just gave you some keywords, but it looks like you need time to rest & a vacation or journey is needed for introspection or strengthening your connection with the Divine or signs from the Divine.
After thinking about them a little more, I want to say that maybe you need to take time off for Memorial Day weekend for yourself. Go on a trip that is all about taking care of you?